![]() Complex angiographic criteria included multivessel coronary artery disease, target lesions requiring total stent length >30 mm, thrombotic target lesion, bifurcation lesions requiring ≥2 stents, left main or proximal left anterior descending artery lesions, and calcified target lesions requiring atherectomy.Īmong 7,119 patients randomized in the main TWILIGHT trial, complex PCI was performed in 2,342 patients. Patients with at least 1 clinical and 1 angiographic criterion for complex PCI were treated with ticagrelor plus aspirin for 3 months followed by either aspirin or placebo and continued on ticagrelor for an additional 12 months.Ĭomplex clinical criteria included age ≥65 years, female gender, troponin-positive acute coronary syndrome (ACS), established vascular disease, diabetes, or chronic kidney disease. ![]() In this prespecified sub-analysis of the TWILIGHT randomized double-blind placebo-controlled trial, the investigators assessed the effect of antiplatelet monotherapy specifically in patients who had been treated with complex PCI. Dangas, MD, PhD, the director of cardiovascular innovation at the Cardiovascular Institute of the Mount Sinai Medical Center, New York, presented on behalf of the TWILIGHT Investigators the results of Ticagrelor With AspIrin or ALone In HiGH-Risk PaTients After Complex Percutaneous Coronary Intervention: The TWILIGHT-Complex Study. Three key late-breaking clinical trials confirmed that ticagrelor without aspirin following percutaneous coronary intervention (PCI) lowers bleeding risk and does not raise thromboembolic risk in comparison with ticagrelor-plus-aspirin therapy across several different types of patients, according to results presented Monday at the American College of Cardiology Scientific Sessions 2020 virtual conference. ![]() ![]() #Tico trial trial2 TWILIGHT substudies, TICO trial compare ticagrelor only to ticagrelor plus aspirin 3 months after PCI ![]()
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